Translational efficiency

In cell biology, translational efficiency or translation efficiency is the rate of mRNA translation into proteins within cells.

It has been measured in protein per mRNA per hour.[1] Several RNA elements within mRNAs have been shown to affect the rate. These include miRNA and protein binding sites. RNA structure may also affect translational efficiency through the altered protein or microRNA binding.[2]

In fungi, it has been shown that it influences fitness, by reducing the lag phase time, and is associated with pathogenesis [3].


See also

References

  1. ^ Schwanhäusser, Björn; Busse, Dorothea; Li, Na; Dittmar, Gunnar; Schuchhardt, Johannes; Wolf, Jana; Chen, Wei; Selbach, Matthias (May 2011). "Global quantification of mammalian gene expression control" (PDF). Nature. 473 (7347): 337–342. Bibcode:2011Natur.473..337S. doi:10.1038/nature10098. PMID 21593866. S2CID 205224972.
  2. ^ Lu, YF; Mauger, DM; Goldstein, DB; Urban, TJ; Weeks, KM; Bradrick, SS (4 November 2015). "IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance". Scientific Reports. 5 16037. Bibcode:2015NatSR...516037L. doi:10.1038/srep16037. PMC 4631997. PMID 26531896.
  3. ^ Guerreiro, Marco Alexandre; Yurkov, Andrey; Nowrousian, Minou; Broders, Kirk; Stukenbrock, Eva H. (January 2026). "Genomic and physiological signatures of adaptation in pathogenic fungi". Nature Communications. 17 (748). doi:10.1038/s41467-026-68330-6. PMID 12820176.
  • [1] Transterm database online


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