TUBA8

TUBA8
Identifiers
Aliases	TUBA8, TUBAL2, tubulin alpha 8, CDCBM8, MACTHC2
External IDs	OMIM: 605742; MGI: 1858225; HomoloGene: 56766; GeneCards: TUBA8; OMA:TUBA8 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	18,146,683 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	121,203,813 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; apex of heart; ; right auricle of heart; ; left ventricle; ; skeletal muscle tissue; ; right hemisphere of cerebellum; ; left testis; ; Brodmann area 9; ; gonad;
	Top expressed in
	muscle of thigh; ; seminiferous tubule; ; triceps brachii muscle; ; temporal muscle; ; medial head of gastrocnemius muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; right ventricle; ; quadriceps femoris muscle; ; vastus lateralis muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; structural constituent of cytoskeleton; GTPase activity;
Cellular component	cytoplasm; microtubule; cytoskeleton; microtubule cytoskeleton;
Biological process	microtubule-based process; cytoskeleton organization; microtubule cytoskeleton organization; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	51807
	53857
	ENSG00000183785
	ENSMUSG00000030137
	Q9NY65
	Q9JJZ2
	NM_018943; NM_001193414
	NM_017379
	NP_001180343; NP_061816
	NP_059075
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin alpha-8 chain is a protein that in humans is encoded by the TUBA8 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183785 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030137 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stanchi F, Corso V, Scannapieco P, Ievolella C, Negrisolo E, Tiso N, et al. (April 2000). "TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse". Biochemical and Biophysical Research Communications. 270 (3): 1111–1118. Bibcode:2000BBRC..270.1111S. doi:10.1006/bbrc.2000.2571. PMID 10772959.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ "Entrez Gene: TUBA8 tubulin, alpha 8".
^ "GeneCards: TUBA8 gene".

Alexandrova N, Niklinski J, Bliskovsky V, Otterson GA, Blake M, Kaye FJ, et al. (September 1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro". Molecular and Cellular Biology. 15 (9): 5188–5195. doi:10.1128/MCB.15.9.5188. PMC 230766. PMID 7651436.
Feierbach B, Nogales E, Downing KH, Stearns T (January 1999). "Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin". The Journal of Cell Biology. 144 (1): 113–124. doi:10.1083/jcb.144.1.113. PMC 2148126. PMID 9885248.
Herreros L, Rodríguez-Fernandez JL, Brown MC, Alonso-Lebrero JL, Cabañas C, Sánchez-Madrid F, et al. (August 2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". The Journal of Biological Chemistry. 275 (34): 26436–26440. doi:10.1074/jbc.M003970200. hdl:10261/135387. PMID 10840040.
Watts NR, Sackett DL, Ward RD, Miller MW, Wingfield PT, Stahl SS, et al. (July 2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings". The Journal of Cell Biology. 150 (2): 349–360. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (December 2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
Saugstad JA, Yang S, Pohl J, Hall RA, Conn PJ (March 2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". Journal of Neurochemistry. 80 (6): 980–988. doi:10.1046/j.0022-3042.2002.00778.x. PMC 2925652. PMID 11953448.
Chen D, Wang M, Zhou S, Zhou Q (December 2002). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". The EMBO Journal. 21 (24): 6801–6810. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
Xu Y, Kulkosky J, Acheampong E, Nunnari G, Sullivan J, Pomerantz RJ (May 2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy". Proceedings of the National Academy of Sciences of the United States of America. 101 (18): 7070–7075. Bibcode:2004PNAS..101.7070X. doi:10.1073/pnas.0304859101. PMC 406467. PMID 15103018.
Campbell GR, Pasquier E, Watkins J, Bourgarel-Rey V, Peyrot V, Esquieu D, et al. (November 2004). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". The Journal of Biological Chemistry. 279 (46): 48197–48204. Bibcode:2004JBiCh.27948197C. doi:10.1074/jbc.M406195200. PMID 15331610.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10) R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
de Mareuil J, Carre M, Barbier P, Campbell GR, Lancelot S, Opi S, et al. (February 2005). "HIV-1 Tat protein enhances microtubule polymerization". Retrovirology. 2 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386.
Giacca M (February 2005). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology. 2 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
Valenzuela-Fernández A, Alvarez S, Gordon-Alonso M, Barrero M, Ursa A, Cabrero JR, et al. (November 2005). "Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection". Molecular Biology of the Cell. 16 (11): 5445–5454. doi:10.1091/mbc.E05-04-0354. PMC 1266439. PMID 16148047.
Canani RB, De Marco G, Passariello A, Buccigrossi V, Ruotolo S, Bracale I, et al. (January 2006). "Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells". AIDS. 20 (1): 5–10. doi:10.1097/01.aids.0000198088.85572.68. PMID 16327313. S2CID 21499158.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183785 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030137 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Stanchi_2000-5] Stanchi F, Corso V, Scannapieco P, Ievolella C, Negrisolo E, Tiso N, et al. (April 2000). "TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse". Biochemical and Biophysical Research Communications. 270 (3): 1111–1118. Bibcode:2000BBRC..270.1111S. doi:10.1006/bbrc.2000.2571. PMID 10772959.

[Dunham_1999-6] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-7] "Entrez Gene: TUBA8 tubulin, alpha 8".

[genecards-8] "GeneCards: TUBA8 gene".

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[3]

[4]

[5]

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References

Further reading