Transmembrane protein 51 is a protein in humans that is encoded by the TMEM51 gene.[5] It is located on the first chromosome (1p36.21) and has 6 isoforms in humans.[6] It has orthologs in mammals, birds, reptiles, amphibians, and fish.[6]
It is predicted to be a transmembrane protein due to the transmembrane regions within its coding sequence.[7]
TMEM51-AS1 (a long non-coding RNA from the TMEM51 locus) acts as a tumor suppressor when overexpressed, inhibiting cancer cell progression.[8] Mutations or polymorphisms of the TMEM51 are associated susceptibility to Reynaud's syndrome.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171729 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040616 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Transmembrane protein 51". Retrieved 2012-10-29.
- ^ a b "AceView: Gene:TMEM51, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2025-09-29.
- ^ "Homo sapiens transmembrane protein 51 (TMEM51), transcript variant 1, mRNA". NCBI. 2025-04-27.
- ^ Wu D, Xia Q, Su X, Mao Y, Mao J, Ding Q, et al. (May 2025). "Long non-coding RNA TMEM51-AS1 inhibits colorectal cancer progression". Discover Oncology. 16 (1) 878. doi:10.1007/s12672-025-02676-z. PMC 12102048. PMID 40407985.
- ^ Tervi A, Ramste M, Abner E, Cheng P, Lane JM, Maher M, et al. (September 2024). "Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity". Cell Genomics. 4 (9) 100630. doi:10.1016/j.xgen.2024.100630. PMC 11480858. PMID 39142284.
Further reading