OR5V1

OR5V1
Identifiers
AliasesOR5V1, 6M1-21, hs6M1-21, olfactory receptor family 5 subfamily V member 1
External IDsMGI: 2177493; HomoloGene: 73968; GeneCards: OR5V1; OMA:OR5V1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

81696

258325

Ensembl

ENSMUSG00000090894

UniProt

Q9UGF6

A2RT31

RefSeq (mRNA)

NM_030876

NM_146328

RefSeq (protein)

NP_110503

NP_666440

Location (UCSC)Chr 6: 29.35 – 29.43 MbChr 17: 37.8 – 37.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 5V1 is a protein that in humans is encoded by the OR5V1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Functional studies of the mouse ortholog (Olfr110) have identified this receptor as a high-affinity sensor for the oxylipin 12(S)-hydroxyeicosapentaenoic acid (12(S)-HEPE), revealing a role beyond classical odorant detection in regulating metabolism. Engagement of this receptor by oxylipins activates Gs-dependent signaling pathways that promote fatty acid oxidation and influence glucose homeostasis, indicating a potential role for OR5V1 in metabolic processes and as a therapeutic target for metabolic disorders.[6]

See also

References

  1. ^ a b c ENSG00000227137, ENSG00000243441, ENSG00000243729, ENSG00000233046, ENSG00000230742, ENSG00000240130, ENSG00000242289 GRCh38: Ensembl release 89: ENSG00000112461, ENSG00000227137, ENSG00000243441, ENSG00000243729, ENSG00000233046, ENSG00000230742, ENSG00000240130, ENSG00000242289 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090894 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR5V1 olfactory receptor, family 5, subfamily V, member 1".
  6. ^ Ge XY, Cheng J, Zhang LJ, Guo LL, Xiang R, Lu Y, et al. (January 2026). "Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target". Cell. doi:10.1016/j.cell.2025.12.016. PMID 41570820.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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