+ 2 reduced ferredoxin
+ ATP + 2 H+
Chlorophyllide a reductase
| Chlorophyllide a reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.7.15 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Chlorophyllide a reductase (EC 1.3.7.15), also known as COR, is an enzyme with systematic name bacteriochlorophyllide-a:ferredoxin 7,8-oxidoreductase.[1][2] It catalyses the following chemical reaction
This reduction, (with trans stereochemistry) of the sidechains in the pyrrole ring, gives the characteristic 18-electron aromatic system that distinguishes bacteriochlorophylls from chlorophylls, which retain the chlorin system of chlorophyllide a.[3] The enzyme uses ferredoxin and adenosine triphosphate as cofactors and gives adenosine diphosphate and phosphate (Pi) as byproducts.[4]
This enzyme is present in purple bacteria such as Rhodobacter capsulatus and Rhodobacter sphaeroides, and Pseudomonadota. It is a component of the biosynthetic pathway to bacteriochlorophylls.[5][6][7]
See also
References
- ^ Harada, Jiro; Mizoguchi, Tadashi; Tsukatani, Yusuke; Yokono, Makio; Tanaka, Ayumi; Tamiaki, Hitoshi (2014). "Chlorophyllide a Oxidoreductase Works as One of the Divinyl Reductases Specifically Involved in Bacteriochlorophyll a Biosynthesis". Journal of Biological Chemistry. 289 (18): 12716–12726. doi:10.1074/jbc.M113.546739. PMC 4007461. PMID 24637023.
- ^ Tsukatani, Yusuke; Harada, Jiro; Nomata, Jiro; Yamamoto, Haruki; Fujita, Yuichi; Mizoguchi, Tadashi; Tamiaki, Hitoshi (2015). "Rhodobacter sphaeroides mutants overexpressing chlorophyllide a oxidoreductase of Blastochloris viridis elucidate functions of enzymes in late bacteriochlorophyll biosynthetic pathways". Scientific Reports. 5 9741. Bibcode:2015NatSR...5.9741T. doi:10.1038/srep09741. PMC 4432870. PMID 25978726.
- ^ Senge, Mathias O.; Smith, Kevin M. (2004). "Biosynthesis and Structures of the Bacteriochlorophylls". Anoxygenic Photosynthetic Bacteria. Advances in Photosynthesis and Respiration. Vol. 2. pp. 137–151. doi:10.1007/0-306-47954-0_8. ISBN 0-7923-3681-X.
- ^ Enzyme 1.3.7.15 at KEGG Pathway Database.
- ^ R. Caspi (2015-12-08). "Pathway: bacteriochlorophyll a biosynthesis". MetaCyc Metabolic Pathway Database. Retrieved 2020-06-04.
- ^ Willows RD (June 2003). "Biosynthesis of chlorophylls from protoporphyrin IX". Natural Product Reports. 20 (3): 327–41. doi:10.1039/B110549N. PMID 12828371.
- ^ Bollivar DW (November 2006). "Recent advances in chlorophyll biosynthesis". Photosynthesis Research. 90 (2): 173–94. doi:10.1007/s11120-006-9076-6. PMID 17370354. S2CID 23808539.