Centromere protein O is a protein that in humans is encoded by the CENPO gene.[5][6][7] CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138092 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020652 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, et al. (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–457. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
- ^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–469. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
- ^ "Entrez Gene: CENPO centromere protein O".
- ^ Hewitt CA, Ling KH, Merson TD, Simpson KM, Ritchie ME, King SL, et al. (July 2010). "Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome". PloS One. 5 (7) e11561. Bibcode:2010PLoSO...511561H. doi:10.1371/journal.pone.0011561. PMC 2905390. PMID 20661276.
External links
Further reading
- Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–120. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, et al. (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–684. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.
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