1T-LSD

1T-LSD
Clinical data
Other names1-(Thiophene-2-carbonyl)-LSD; SYN-L-021
Routes of
administration		Oral
Drug classSerotonergic psychedelic; Hallucinogen
Identifiers
  • (6aR,9R)-N,N-diethyl-7-methyl-4-(thiophen-2-yl)methanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC25H27N3O2S
Molar mass433.57 g·mol−1
3D model (JSmol)
  • O=C(n1cc2C[C@@H]3C(=C[C@H](CN3C)C(=O)N(CC)CC)c3cccc1c32)c1cccs1

1T-LSD, also known as 1-(thiophene-2-carbonyl)-LSD or as SYN-L-021, is an acylated derivative of lysergic acid diethylamide (LSD), which has been sold as a designer drug.[1][2] It was first identified in Japan in 2023 on blotter paper misrepresented as containing 1D-LSD, but which on analysis was determined to contain 1T-LSD instead.[3] It was also detected in Germany around the same time.[4]

Use and effects

See also: LSD § Uses, and LSD § Effects

A 150 μg dose of 1T-LSD is said to be equivalent to 100 μg LSD.[2] Doses of 87 to 100 μg 1T-LSD have been encountered in blotter tabs.[1]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Chemistry

Analogues

Analogues of 1T-LSD include ALD-52 (1A-LSD), 1P-LSD, 1B-LSD, 1V-LSD, 1DD-LSD, and 1T-AL-LAD, among others.

Society and culture

Canada

1T-LSD is not a controlled substance in Canada as of 2025.[5]

United States

1T-LSD is not an explicitly controlled substance in the United States.[6] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

References

  1. ^ a b "1T-LSD". АИПСИН (in Russian). 21 August 2023. Retrieved 1 January 2026.
  2. ^ a b "1T-LSD". АИПСИН (in Russian). Retrieved 1 January 2026.
  3. ^ Okada Y, Ueno K, Nishiwaki N, Nishimura T, Segawa H, Yamamuro T, et al. (July 2023). "Identification of 1-(thiophene-2-carbonyl)-LSD from blotter paper falsely labeled "1D-LSD"". Forensic Toxicology. 42 (1): 93–101. doi:10.1007/s11419-023-00668-8. PMID 37421500. S2CID 259374662.
  4. ^ "New psychoactive substances - the current situation in Europe" (PDF). European Drug Report. European Union Drugs Agency (EUDA). 2024.
  5. ^ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
  6. ^ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
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